Increasing Power of Groupwise Association Test with Likelihood Ratio Test

Increasing Power of Groupwise Association Test with Likelihood Ratio Test

Sequencing studies have been discovering a numerous number of rare variants, allowing the identification of the effects of rare variants on disease susceptibility. As a method to increase the statistical power of studies on rare variants, several groupwise association tests that group rare variants in genes and detect associations between genes and diseases have been proposed. One major challen...

1 Likelihood Ratio Test ( LRT

A Likelihood-Ratio Test of Monophyly

?Many phylogenetic analyses are inspired by or depend upon the monophyly of a group specified a priori. Also, many evolutionary problems for which phylogenies are useful do not require every detail of the phylogeny to be estimated correctly but depend upon the monophyly (or lack thereof) of a particular group. We propose a likelihood-ratio test that compares whether the best trees estimated wit...

A Mean Likelihood Ratio Speci cation Test

This paper considers the problem of speci cation testing in general parametric models and shows that for a wide class of models the hypothesis of correct speci cation is equivalent to a continuum of moment equalities. Using these moment equalities we construct a class of speci cation tests that have correct asymptotic size in general parametric models, including stationary time series models, a...

Generalized Likelihood Ratio Test for Selecting

A generalized likelihood ratio test is considered for testing acoustic propagation models in the context of environmental parameter inversion. In the following, we use the term \hierarchy of models" to denote a sequence of model structures M1;M2;... in which each particular model structure Mn contains all previous ones as special cases. We propose a combined parameter estimation and multiple se...